| 产品名称 | AMPK (A2/ B1/G1), His-tag - Serine-Threonine Kinases - Kinase(s) |
| 产品货号 | 40704 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 5 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: Sf9 insect cells
MW: ~148 kDa (complex)
Genbank #: NM_006252 (A2), NM_006253 (B1), NM_002733 (G1)
Tag(s): C-terminal His-tag
a.a: full length
Background: AMPK (A2/B1/G1) plays a key role in insulin signaling pathway and is a major therapeutic target for the treatment of diabetes (1). AMPK is viewed as a fuel sensor for glucose and lipid metabolism by modulating the activity of the autonomous nervous system in vivo. Short-term overexpression of a constitutively active form of AMPK in the liver leads to mild hypoglycemia and fatty liver due to increased fatty acid utilization (2).
Description: Recombinant human AMPK (combination of A2/B1/G1 subunits), full length, with C-terminal His-tag, expressed in Sf9 insect cells via a baculovirus expression system.
Synonym(s): Subunit A2: PRKAA2, AMPK, AMPK2, PRKAA
Subunit B1: PRKAB1, AMPK, HAMPKb, MGC17785 Subunit G1: PRKAG1, AMPKG, MGC8666 Purity: ≥75%
Formulation: 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol.
Format: Aqueous buffer solution
Storage / Stability: >6 months at -80°C. Application(s): Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s): 1. Viollet, B. et al: Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models. Biochem. Soc. Trans. 2003; 31; 216–219.
2. Foretz, M. et al: Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. Diabetes, 2005; 54 (5);1331-1339. Warning(s): Avoid freeze/thaw cycles
Scientific Category: Kinase/Serine-Threonine
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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