| 产品名称 | ML161 - Other - Inhibitors / Activators |
| 产品货号 | 27764-1 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 361.2 Da
CAS Registry #: 423735-93-7
Formula: C17H17BrN2O2
Target: PAR-1
Background: ML-161 is thought to act allosterically. ML-161 inhibits thrombin-induced platelet activation.
Description: Allosteric and reversible inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 µM for the inhibition of platelet P-selectin expression on human platelets).
Synonym(s): 2-bromo-N-[3-(butanoylamino)phenyl]benzamide
Biological Activity: ML-161 is an antagonist of the protease-activated receptor 1 (PAR1), that inhibits thrombin and SFLLN-induced platelet activation. ML-161 dose dependently inhibits SFLLN-induced expression of P-selectin with an IC50 of 0.26 µM.
Solubility: Soluble in DMSO
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. Reference(s): Dockendorff, C., et al. 2012. ACS Med. Chem. Lett. 3: 232-237
Scientific Category: Other inhibitors
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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