Epacadostat (INCB024360) is an orally available hydroxyamidine and inhibitor of indoleamine 2,3- dioxygenase (IDO1), with an IC50 of 10 nM. It shows little activity against other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO). Epacadostat displays potential immunomodulating and antineoplastic activities.
| 产品名称 | Epacadostat (INCB024360) - Other - Inhibitors / Activators |
| 产品货号 | 27339-1 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 438.2 Da
CAS Registry #: 1204669-58-8
Formula: C11H13BrFN7O4S
Description: Synonym(s): INCB024360, INCB24360, IDO inhibitor
Purity: ≥98%
Biological Activity: Epacadostat has been reported to restore and increase the proliferation of
various immune cells including dendritic cells, NK cells, and T cells in vitro and in vivo.
Solubility: Soluble in DMSO.
Format: White powder
Storage / Stability: Store as supplied at or below -20°C for up to 2 years. Stable in DMSO at
-80°C for up to 6 months.
Reference(s): 1. Koblish, HK., et al., Molec. Cancer Therapeutics. 2010; 9: 489-498. Scientific Category: Immunotherapy
Product Type: Inhibitors/Activators
Data shown is lot-specific. Contact us for specific information on other lots.
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