Curcumin, also known as diferuloylmethane, natural yellow 3, or C.I. 75300, is the principal curcuminoid of the popular Indian spice turmeric, which is a small molecule, selective HAT inhibitor. It has shown to promote degradation of p300 and inhibits the acetyltransferases activity of purified p300 using either histone H3 or p53 as a substrate.

Curcumin, diferuloylmethane, natural yellow 3, C.I. 75300

≥94% by HPLC

Acetylation of histones H3 and H4 by p300/CBP was strongly inhibited by curcumin with an IC50 25 µM.

Soluble in acetone, ethanol and DMSO.

Yellow powder.

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

1. Marcu, MG. et al., Med. Chem. 2006 Mar; 2(2): 169-174.
2. Kundu, TK. et al., Journal of Biological Chemistry (2004); 279(49):51163-51171.

Miscellaneous

Inhibitor