BAY-11-7082 is a selective and irreversible inhibitor of NF-κB activation by blocking TNF-α-induced phosphorylation of IκB-α without affecting constitutive IκB-α phosphorylation. It also inhibits the TNF-α-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin in human endothelial cells.
| 产品名称 | BAY-11-7082 - Other - Inhibitors / Activators |
| 产品货号 | 27229 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 207.3 Da
CAS Registry #: 19542-67-7
Formula: C10H9NO2S
Description: Purity: ≥98% by HPLC Biological Activity: BAY-11-7082 inhibits TNF-α-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin with IC50 values of 5-10 µM.
Solubility: Soluble in ethanol, DMSO and DMF, purged with an inert gas. Solubility in ethanol is
~ 0.20 mg/ml, and in DMSO and DMF is 25 mg/ml.
Format: A crystalline solid.
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s): 1. Pahl, H., et al., Oncogene. 1999;18:6853-6866.
2. Gilmore, TD, et al., Oncogene. 1999;18:6842-6844. 3. Karin, M., et al., J. Biol. Chem. 1999;274(39):27339-27342. Scientific Category: Miscellaneous
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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