| 产品名称 | XAV939 - PARP - Inhibitors / Activators |
| 产品货号 | 27100 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 312.3 Da
CAS Registry #: 284028-89-3
Formula: C14H11F3N2OS
Description: XAV 939 is a small molecule and selective Wnt pathway transcription factor - catenin-mediated transcription inhibitor and axin stabilizing agent. It stimulates beta-catenin degradation by stabilizing axin, the concentration-limiting component of the destruction complex and stabilizes axin by inhibiting the poly-ADP-ribosylating enzymes tankyrase 1 (TNKS1) and tankyrase 2 (TNKS2).
Purity: ≥99% by HPLC Biological Activity: XAV939 inhibited TNKS1 and TNKS2 with IC50 of 4.6 nM and 1.68 nM, respectively using BPS Bioscience TNKS1 Assay Kit (Cat. # 80564) and TNKS2 Assay Kit (Cat. # 80566).
Solubility: Soluble in DMSO at 25 mg/ml.
Format: White to beige powder.
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s): Huang, SM. et al. Nature. 2009 Oct 1; 461(7264):614-20.
Scientific Category: PARP
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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