Rolipram is a selective, cell permeable inhibitor of cAMP-specific phosphodiesterase 4 (PDE4). PDE4 enzymes inactivate cyclic AMP (cAMP) via hydrolysis to 5'-AMP. Rolipram has two enantiomeric forms, R(-) and S(+). This product is the racemic mixture of the two enantiomers.

≥95% by HPLC.

Rolipram inhibited PDE4 with IC50=1µM using the BPS Bioscience PDE4A Assay Kit (Cat. # 60340).

Soluble in DMSO (25 mg/ml warm) and Ethanol (25 mg/ml warm).

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

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