LY171883 is a PDE inhibitor and a selective, potent inhibitor of the leukotriene D4 receptor. Also, LY171883 binds to the PPAR nuclear receptor at 50-100 ?M and induces adipogenesis in cultured NIH3T3 fibroblasts.

≥98% by HPLC

LY171883 inhibits PDEs from human polymorphonuclear leukocytes with an IC50 of 22.6 µM, and from guinea pig tissues with an IC50 range from 6.9 – 209 µM.

Soluble in ethanol, DMSO and DMF, purged with an inert gas. Solubility in ethanol, DMSO and DMF is approximately 25 mg/ml. For maximum solubility in aqueous buffers, dissolve directly in 0.5 M Na₂CO₃ (15 mg/ml) then dilute with PBS (pH 7.2) to the desired concentration or pH.

A crystalline solid.

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

1. Fleisch, J.H., et al., J. Pharmacol. Exp. Ther. 1985; 233: 148-157
2. Forman, B.M., et al., Cell. 1995; 83: 803-812.
3. Tontonoz, P., et al., Cell. 1994; 79: 1147-1156.

PDE

Inhibitor