| 产品名称 | Aminophylline - Phosphodiesterase - Inhibitors / Activators |
| 产品货号 | 27731 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 25 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 420.4 Da
CAS Registry #: 317-34-0
Formula: C16H24N10O4
Target: PDE
Background: Aminophylline is a bronchodilator that is used together with other medicines to treat the acute symptoms of asthma, bronchitis, emphysema, and other lung diseases. Aminophylline is also a competitive adenosine receptor antagonist and it is thought to have potential therapeutic value for cardiac ischemia.
Description: Aminophylline is a non-selective phosphodiesterase (PDE) inhibitor with an IC50 of 0.12 mM. Inhibition of PDE prevents the breakdown of secondary messenger molecules cAMP and cGMP, which play a vital role in signal transduction.
Synonym(s): theophylline ethylenediamine; bis(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione); ethane-1,2-diamine
Solubility: Soluble in water (3.7 mg/ml). Solutions should be freshly prepared. Not soluble in alcohols.
Format: white to off-white powder
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. Reference(s): 1. Crisanti, et al., Am. J. Physiol. 277, R829-R835, (1999).
2. Chanda, et al., Pol. J. Pharmacol. 50, 80-82, (1998). 3. Thakker, et al. Analytical Profiles of Drug Substances 2nd ed., (1982) 2, 1-44. Scientific Category: PDE Inhibitor
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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