CTPB is a potent activator of p300 activity, but not of PCAF (p300/CBP-associated factor). This compound has been shown to enhance p300 HAT-dependent transcriptional activation from in vitro assembled chromatin template. CTPB has also been noted to be a membrane-impermeable molecule that requires a carrier to move across the membrane barrier of cells.

N-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxy-6-pentadecyl-benzamide, cbp

≥97%

Soluble in DMSO

White to off-white crystalline solid.

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

1. Balasubramanyam, K., et al. 2003. J. Biol. Chem. 278: 19134-19140.
2. Campo, N., et al. 2007. J. Bacteriol. 189: 6021-6027.

Protect from light and air.

Acetyltransferase

Activator