Azacitidine is also known as Vidaza, 5-azacytidine, Mylosar, and Ladakamycin. Azacitidine and its deoxy derivative, decitabine (5-aza-2'deoxycytidine), are used in the treatment of myelodysplastic syndrome. The azacytidine in the DNA forms a stable complex with DNA methyltransferase enzymes, preventing DNMT activity and resulting in hypomethylation of cellular DNA. Likewise, the incorporation of azacytidine into RNA leads to the dissembly of polyribosomes, defective methylation and inhibition of protein production with subsequent cytotoxicity.
| 产品名称 | Azacytidine (Vidaza) - Methyltransferase - Inhibitors / Activators |
| 产品货号 | 27107 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 50 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 244.2 Da
CAS Registry #: 320-67-2
Formula: C8H12N4O5
Description: Synonym(s): Vidaza, 5-azacytidine, Mylosar, and Ladakamycin
Purity: ≥99% by HPLC Biological Activity: When testing anti-tumor effects in prostate cancer the antiproliferative effect of azacitidine treatment in 22rv1 cells and PC3 cells, the IC50’s were 0.5 µM and 2.5 µM respectively. Solubility: Soluble in DMSO. Insoluble in acetone, ethanol, and methyl ethyl ketone. Slightly soluble in
ethanol/water combination of fifty-fifty, and propylene glycol.
Format: White to off-white solid
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s): Vigushin DM et al. Clin Cancer Res. 2001 Apr;7(4):971-6.
Scientific Category: DNMT
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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