| 产品名称 | XL-888 - Metabolic Enzymes - Inhibitors / Activators |
| 产品货号 | 27781-2 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 5 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 503.6 Da
CAS Registry #: 1149705-71-4
Formula: C29H37N5O3
Target: HSP90
Background: X-ray crystallographic analysis reveals that the XL-888 binds to HSP90 through the formation of H-bonding between the N-(R)-sec-butylanthranilamide moiety of XL-888 and ASP93 of HSP90.
Description: XL-888 is a novel and orally-bioavailable inhibitor of heat shock protein 90 (HSP90) that selectively inhibits HSP90α and HSP90β with IC50s of 22 nM and 44 nM respectively. It also exerts considerably weaker inhibition against a range of other diverse kinases with IC50 more than 3600 nM for all. In recent studies, XL-888 has exhibits strong anti-proliferative activities in a panel of tumor cells with values of IC50 ranging from 0.1 nM to 45.5 nM.
Synonym(s): Xl 888; Xl888; 2-(butan-2-ylamino)-4-N-[(1R,5S)-8-[5-(cyclopropanecarbonyl)pyridin-2-yl]-8-azabicyclo[3.2.1]octan-3-yl]-5-methylbenzene-1,4-dicarboxamide
Solubility: Soluble in DMSO
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. Reference(s): 1. Paraiso KH, et al. Clin Cancer Res. 2012; 18(9):2502-2514.
2. Bussenius J, et al. Bioorg Med Chem Lett. 2012; 22(17): 5396-5404. Scientific Category: HSP Inhibitor
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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