Dihydrochloride form of HA-1077. Inhibits a number of kinases, including ROCK I (IC50 = 10.7 µM), ROCK II (IC50 = 1.9 µM), MAPK1 (IC50 = 5 µM), and PKCRK2 (IC50 = 4 µM). Weaker inhibitor of PKC (IC50 = 425 µM) and MLCK (IC50 = 95 µM) .

Fasudil, Dihydrochloride Salt, 1-(5-Isoquinolinesulfonyl)homopiperazine, 2HCl, Eril, AT-877

≥99%

Very soluble in water, up to 200 mg/ml or more; soluble in DMSO up to about 10 mg/ml; not soluble in ethanol; addition of an aqueous solution of this dihydrochloride salt into a buffer solution may significantly alter its solubility

White crystalline powder.

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Davies, S.P. et al. Biochem. J. 351: 95-105 (2000).

Kinase

Inhibitor