MS-275, also known as Entinostat, is an inhibitor of histone deacetylases (HDACs) and preferentially inhibits HDAC1 over HDAC3. It does not inhibit HDAC8 (IC50 > 100 µM). It induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in vivo. Recent studies suggest that MS-275 may be particularly useful as an antineoplastic agent when combined with other drugs like adriamycin, inhibitors of PARPs, or inhibitors of Hsp90.
| 产品名称 | MS-275 (Entinostat) - Deacetylase - Inhibitors / Activators |
| 产品货号 | 27011 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 25 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 376.4 Da
CAS Registry #: 209783-80-2.
Formula: C21H20N4O3
Description: Synonym(s): MS-275, Entinostat
Purity: ≥99% by HPLC. Biological Activity: MS-275 inhibits HDAC1 with an IC50 of 300 nM and HDAC3 with an IC50 value of 8 µM.
Solubility: Soluble in DMSO at 25 mg/ml with slight warming. MS-275 is poorly soluble in ethanol and water.
Format: White to off-white crystalline solid.
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s): 1. Hu., E. et al., J. Pharmacol. Exp. Ther. 2003; 307: 720-728. Application Reference:
Scientific Category: HDAC
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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