M344 is a histone deacetylase (HDAC) inhibitor also known as D237 or MS 344. It inhibits human HDACs, and shows a three-fold selectivity for inhibition of HDAC6 over HDAC1. M344 has been found to increase the sensitivity of human squamous carcinoma cells to radiation. It has also been found to promote cell cycle arrest and apoptosis in human ovarian cancer cells and endometrial cancer. M344 can also inhibit maize HDAC.

M344, D237, MS 344

≥98% by HPLC.

M344 inhibits human HDAC6 with an IC50 of ~14 nM and HDAC1 at ~46 nM.

Soluble in ethanol is ~3 mg/ml and ~25 mg/ml in DMSO and DMF. For biological experiments, dilute the organic solvent into aqueous buffers or isotonic saline.

A crystalline solid

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

1. Jung, M., et al., J. Med. Chem. 1999; 42: 4669-4679.
2. Remiszewski, S., et al., J. Med. Chem. 2002; 45(4): 753-757.
3. Heltweg, B., et al., J. Med. Chem. 2004.; 47: 5235-5243.

HDAC

Inhibitor