HC Toxin is a reversible, cell-permeable inhibitor of HDACs. It is a cyclic tetrapeptide first isolated from C. carbonum, a maize pathogen. It up-regulates the expression of 15-lipoxygenase-1 in colorectal cancer cells and has been shown to induce fetal hemoglobin in human primary erythroid cells.

≥95% by HPLC.

HC Toxin inhibits HDACs with an IC50 = 30 nM.

Soluble in methanol, purged with an inert gas. Solubility in methanol is approximately 10 mg/ml. For organic solvent-free aqueous solutions, prepare by directly dissolving the crystalline compound in aqueous buffers.

A crystalline solid

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

1. Brosch, G., et al., Plant Cell. 1995; 7: 1941-1950.
2. Darkin-Rattray, SJ, et al., Proc. Natl. Acad. Sci. USA. 1996; 93(23): 13143-13147.
3. Kamitani, H., et al., Carconogenesis. 2001; 22(1): 187-191.

HDAC

Inhibitor