EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor. It is Selective inhibitor of SIRT1 that does not class I/II inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members. EX 527 has been used a powerful tool for studying the relationship between SIRT1 and cell regulation.

≥99% by HPLC

EX-527 inhibits SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 38 nM. IC50 values are 98 nM, 19.6 µM, 48.7 µM, >100 µM and > 100 µM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively.

Soluble in DMSO.

White to beige powder.

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

1. Solomon, JM et al. Mol Cell Biol. 2006 Jan;26(1):28-38
2. Huhtiniemi, T et al. J Med Chem. 2008 Aug 14;51(15):4377-80

Application Reference(s):
1. Cyclocarya paliurus extract activates insulin signaling via Sirtuin1 in C2C12 myotubes and decreases blood glucose level in mice with impaired insulin secretion (2017)

HDAC

Inhibitor