AICAR, also known as acadesine, is an adenosine regulating agent and AMPK activator. AICAR was found to activate AMP-activated protein kinase (AMPK) in skeletal muscle, inhibit acetyl-CoA carboxylase, reduce malonyl-CoA, and increase fatty acid oxidation and glucose uptake. Note: This product is not 5'-phosphorylated.

Acadesine, AIC -Riboside, 5-Aminoimidazole-4-carboxamide riboside

≥99%

Soluble in DMSO at 40 mg/ml; soluble in ethanol at 2 mg/ml with warming; soluble in water at 20 mg/ml with warming

Tan powder

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Merrill, G.F., et al. Am. J. Physiol. 273: E1107-E1112 (1997).

ACC

Inhibitor