| 产品名称 | Histone Octamer H3K27cMe3, His-tag - Substrates - Demethylase(s) |
| 产品货号 | 52091 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 50 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: E. coli
MW: 116 kDa
Genbank #: NM_033445, NM_003528, NM_003532, and NM_003548
Tag(s): N-terminal His-tag
Background: The histone octamer is composed of a central heterotetramer of two copies of both histones H3 and H4, flanked by two heterodimers of histones H2A and H2B. The octamer assembles when the H3/H4 tetramer complexes with two H2A/H2B dimers. These histones of the histone octamer all contain N-terminal tails that emanate from their central histone folds and are targets for epigenetic modification.
Description: Human recombinant histone octamer consisting of 2 molecules each of histones H2A (a.a. 1-130(end)), H2B (a.a. 1-126(end)), H3 (a.a. 1-136(end)), and H4 (a.a. 1-103(end)), expressed in an E. coli expression system. Each histone protein has an N-terminal His-tag. Histone H3 has K27C, C97A, and C111A mutations and was alkylated to produce the lysine analog, trimethyl aminoethylcysteine. GenBank Accession Nos. are NM_033445, NM_003528, NM_003532, and NM_003548, respectively. Global MW = 116 kDa.
UniProt P68431
Formulation: 45 mM Tris pH 7.5, 2 M NaCl, and 10% glycerol
Format: Aqueous buffer solution
Storage / Stability: >6 months at –80°C.
Application(s): A perfect substrate for histone methyltransferases and demethylases.
Reference(s): 1. Simon, M.D., et al. Cell 2007; 128: 1003-1012.
2. Raut, V.V., Pandey, S.M., Sainis, J.K. Ann Bot. 2011; 108(7):1235-46 Warning(s): Avoid freeze/thaw cycles.
Scientific Category: Demethylase
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
|
| 产品资料 |
