Chidamide is a histone deacetylase inhibitor which increases Histone H3 acetylation levels in LoVo and HT29 colon cancer cells at low concentrations (4 µM). Chidamide affects the activation of oncogenic signaling kinases by dose-dependently reducing phosphorylated Akt, mTOR, p70S6K, Raf and Erk 1/2 protein expression in colon cancer cells. Chidamide also dose-dependently upregulates p21 protein expression, down-regulates CDK4, and induces cell cycle arrest at the G0/G1 phase.
| 产品名称 | Chidamide - Inhibitors / Activators - Deacetylase(s) |
| 产品货号 | 27202 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 1 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 390.4 Da
CAS Registry #: 743420-02-2
Formula: C22H19FN4O2
Description: Purity: ≥98% by HPLC. Biological Activity: Chidamide has shown an IC50 ranging from 1 – 13 µM using an MTT assay performed on human cancer cell lines.
Solubility: Soluble in DMSO and DMF. Sparingly soluble in aqueous buffers. For maximum solubility, dissolve first in DMSO and then dilute with aqueous buffer of choice.
Format: White to off-white crystalline solid.
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s): 1. Liu, L., et al., Biochem. Biophys. Res. Commun. 2010; 392: 190-195.
2. Wang, H., et al., Mol Med Report. 2012 Apr 5. doi: 10.3892/mmr.2012.858. [Epub ahead of print] Scientific Category: HDAC
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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