| 产品名称 | (-)-JQ1 - Inhibitors / Activators - Bromodomain(s) |
| 产品货号 | 27335 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 25 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 457.0 kDa
CAS Registry #: 1268524-71-5
Formula:
C23H25ClN4O2S Background: (-)-JQ1 is the inactive stereoisomer of the potent, cell-permeable, small molecule
bromodomain inhibitor (+)-JQ1 that competitively binds to acetyl-lysine recognition motifs. (+)-JQ1
competitively binds to the bromodomain displacing the BRD4 fusion oncoprotein from chromatin,
which induces squamous differentiation and specific anti-proliferative effect in BRD4-dependent cell
lines and patient-derived xenograft models. However, study results have shown that (-)-JQ1 fails to
significantly interact with any bromodomain tested and exhibits inhibition against BRD4(1) with and
IC50 of 10,000 nM.
Synonym(s): (R)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Biological Activity: (-)-JQ1 showed no inhibition of BRD4-dependent NMC cells.
Solubility: Soluble in DMSO or ethanol at 100 mM
Storage / Stability: Store at or below -80°C. Stable for less than 6 months when stored as directed.
Reference(s): Filippakopoulos, P., et al. Nature. 2010 Dec 23;468(7327):1067-73 Application Reference:
Warning(s): Avoid freeze/thaw cycles.
Scientific Category: Bromodomain
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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