| 产品名称 | Anti-CD47 Antagonist Antibody - Cell Surface Receptor - Antibodies |
| 产品货号 | 79065-1 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 50 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: HEK293
MW: Heavy Chain: 51 kDa, Light Chain: 27 kDa
Clonality: Monoclonal
Isotype: IgG1
Background: Cluster of Differentiation 47, or CD47, plays an essential role in cell growth, death, migration, and adhesion. CD47 binding to SIRP-α mediates phagocytosis by sending a “do not eat me” signal to phagocytes. CD47 proteins are often over expressed by tumor cells as a means for them to escape phagocytosis. As a result, cancerous tumor cells have the ability to proliferate and evade the immune system.
Description: Anti-CD47 recombinant human antagonist antibody recognizing the SIRP-α or SIRP-ү binding region of human CD47. This antibody has not been tested for cross-reactivity with any other species.
Formulation: 8 mM Phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Purification: Protein A affinity chromato-graphy from HEK293 supernatants.
Storage / Stability: Stable for at least 12 months at -80°C. Protect from light. Avoid freeze/thaw cycles. Store diluted antibody with carrier protein (BSA 0.1 – 0.5%) at 4°C, stable for 2 weeks.
Application(s): Useful as an antagonist to block CD47 signaling and binding to SIRP-α or SIRP-ү in biochemical assays.
Reference(s): 1. Vernon-Wilson, E.F. et al., Eur. J. Immunol. 2000; 30(8): 2130-2137.
2. Majeti, R. et al., Cell. 2009; 138(2): 286- 299. Scientific Category: Immunotherapy
Product Type: Antibody
Data shown is lot-specific. Contact us for specific information on other lots.
|
| 产品资料 |
