| 产品名称 | Tau-316 Protein - Proteins - Neuroscience |
| 产品货号 | 90327 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 20 μg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: E. coli
MW: 39 kDa
Genbank #: P10636-3
Tag(s): No Tag
a.a: full length
Background: Tau-316 encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. Tau-316 transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type (1). Tau-316 gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy (2).
Description: Human Tau-316, GenBank Accession No. P10636-3, full length, expressed in an E. coli expression system. MW = 39 kDa.
Synonym(s): Tau
Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Storage / Stability: Store product at –80°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Application(s): Kinase Assay, Western Blot
Reference(s): 1. Brown, J.et.al: Familial dementia with swollen achromatic neurons and corticobasal inclusion bodies: a clinical and pathological study. J. Neurol. Sci. 135: 21-30, 1996.
2. Alonso, A. D. C. et.al: Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nature Med. 2: 783-787, 1996. Scientific Category: Neuroscience
Product Type: Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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