| 产品名称 | DNA Polymerase γ (POLG), His-FLAG-tag - Proteins - Molecular Biology Tools |
| 产品货号 | 21001 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 100 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: Sf9 insect cells
MW: 141 kDa
Genbank #: NM_002693
Tag(s): N-terminal His-FLAG-tag
a.a: 2–1239 (end)
Background: POLG is the catalytic subunit of the mitochondrial DNA polymerase. The catalytic subunit contains three enzymatic activities, a DNA polymerase activity, a 3’-5’ exonuclease activity that proofreads misincorporated nucleotides, and a 5’-dRP lyase activity required for base excision repair. Mutations in the POLG gene are associated with several mitochondrial diseases, including Alpers' disease, ataxia-neuropathy disorders, and dominant and recessive forms of progressive external ophthalmoplegia.
Description: Human DNA polymerase γ (gamma), also known as Pol gamma and POLG (GenBank Accession No. NM_002693), a.a. 2-1239 (end), with N-terminal His-tag and N-terminal FLAG-tag, MW=141 kDa, expressed in a baculovirus infected Sf9 cell expression system.
Synonym(s): DNA polymerase gamma, Pol gamma, POLG
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 80 µg/ml FLAG peptide, 0.04% Tween-20, and 20% glycerol. Format: Aqueous buffer solution
Storage / Stability: >6 months at -80°C. Application(s): Useful for DNA synthesis and DNA repair, as an antigen for Western blotting, and for inhibitor screening.
Reference(s): 1. Ropp, P.A., and Copeland, W.C., Genomics 1996;36(3):449-458. Application Reference(s):
Warning(s): Avoid freeze/thaw cycles
Scientific Category: Molecular Biology
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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