Anti-CD137 recombinant human antibody recognizing the CD137 ligand binding region. This antibody not been tested for cross-reactivity with other species.

Antibody, Anti CD137, Anti-CD137

8 mM Phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.

Protein A affinity chromatography from HEK293 supernatants.

Stable for at least 12 months at -80°C. Avoid freeze/thaw cycles. Store diluted antibody with carrier protein (BSA 0.1 – 0.5%) at 4°C, stable for 2 weeks.

CD137 agonist antibody prevents tumor recurrence and metastases in cancer patients. This antibody is useful for activation of CD137 costimulatory pathway in T cells.

1. Wilcox, R.A., et al., J. Clin. Invest. 2002; 109(5): 651-659.
2. Foell, J. et al., J. Clin. Invest. 2003; 111(10): 1505-1518.

Avoid freeze/thaw cycles.

Immunotherapy

Antibody