| 产品名称 | PSMA (FOLH1) - CHO Recombinant Cell Line (High, Medium, or Low Expression) - CAR T-Cell Therapy Cell Lines - CAR T-Cell Therapy |
| 产品货号 | 79641-H 79641-M 79641-L |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 2 Vials 2 Vials 2 Vials |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Background: PSMA (prostate-specific membrane antigen), also known as Folate hydrolase 1 (FOLH1), is expressed at high levels on prostate cancer cells. It has been reported to play a role in tumor progression through the PI3K-Akt and MAPK-ERK1/2 pathways. PSMA/FOLH1 has been used as a target for imaging prostate cancer and is expressed in other tumor types and some normal tissues. Currently, PSMA/FOLH1 is the target of clinical trials of CAR-T cells and bi-specific antibodies.
Description: Recombinant clonal stable CHO cell line constitutively expressing full length human PSMA protein (Genbank #NM_004476.1). Surface expression of PSMA was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of PSMA expression to mimic different stages of cancer target cells with various PSMA expression levels.
Synonym(s): FOLH1
Supplied As: Each vial contains ~ 2 x 10^6 cells in 1 ml of FBS + 10% DMSO.
Host Cell line: Chinese Hamster Ovary
Mycoplasma Testing: This cell line has been screened using the Quick Test Mycoplasma Detection Kit (Biotool.com, #B39032) to confirm the absence of Mycoplasma contamination.
Growth Media: Thaw Medium 3 (BPS Bioscience, #60186): Ham’s F-12 medium (Hyclone #SH30526.01) supplemented with 10% FBS (Life technologies #26140-079), 1% Penicillin/Streptomycin (Hyclone #SV30010.01). Growth Medium 3B (BPS Bioscience, #79529): Thaw Medium 3 (BPS Bioscience, #60186) plus 500 mg/ml Hygromycin (Thermo Fisher/Life Technologies, #10687010). Instructions for use: See data sheet for detailed culturing and assay protocol.
Storage / Stability: Store in liquid nitrogen immediately upon receipt.
Application(s): Useful for screening and validating antibodies against PSMA and PSMA CAR-T for immunotherapy research and drug discovery. Also useful for PSMA binding assays to screen for PSMA ligands.
Notes: LICENSE DISCLOSURE: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit the use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of BPS products to your laboratory. BPS does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact sales@bpsbioscience.com for details. Publications using this cell line should reference BPS Bioscience, Inc., San Diego. Warning(s): Avoid freeze/thaw cycles.
Scientific Category: CAR T
Product Type: Cell Line
Data shown is lot-specific. Contact us for specific information on other lots.
|
| 产品资料 |
