| 产品名称 | BCMA:APRIL[Biotinylated] Inhibitor Screening Assay Kit - CAR T-Cell Therapy |
| 产品货号 | 79722 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 96 Reactions |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Background: A proliferation-inducing ligand (APRIL, TNSF13 or CD256) and B-cell maturation antigen (BCMA, also known as TNFRSF17 or CD269) create a signaling pathway that participates in the regulation of B-cell development, autoimmunity and long-term plasma cell survival. APRIL expression is significantly elevated in multiple myeloma (MM) and it has been demonstrated that activation of BCMA by APRIL promotes tumor growth, chemoresistance and immunosuppression in the bone marrow microenvironment. Anti-APRIL monoclonal antibodies have been recently progressed to clinical trials for MM.
Description: The BCMA:APRIL[Biotinylated] Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of BCMA:APRIL. The key to this kit is the high sensitivity of detection of biotin-labeled APRIL by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, BCMA is coated on a 96-well plate. Next, biotinylated APRIL is incubated with BCMA on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which can be measured using a chemiluminescence reader.
Materials Required But Not Provided: PBS (Phosphate buffered saline) Synonym(s): TNFRSF17, BCM, BCMA, CD269, TNFRSF13A, tumor necrosis factor receptor superfamily member 17, TNF receptor superfamily member 17
Format:
Instructions for use: See assay protocol for detailed instructions.
Storage / Stability: Up to 6 months from date of receipt, when stored as recommended.
Application(s): This kit is useful for screening for inhibitors of BCMA binding to APRIL.
Reference(s): 1. Yu, G., et al. Nature Immunol. 2000, 1(3): 252 Warning(s): Avoid multiple freeze/thaw cycles.
Scientific Category: Immunotherapy
Product Type: Assay Kit
Data shown is lot-specific. Contact us for specific information on other lots.
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