| 产品名称 | Cathepsin B Inhibitor Screening Assay Kit - Assay Kits - Apoptosis |
| 产品货号 | 79590 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 96 reactions |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Background: Cathepsin B is a cysteine protease that primarily functions as an endopeptidase within endolysosomal compartments in normal cells. High levels of cathepsin B are found in a wide variety of human cancers and in experimental models, such as transgenic models of murine pancreatic and mammary carcinomas, causal roles for this protein have been demonstrated in initiation, growth/tumor cell proliferation, angiogenesis, invasion, and metastasis.
Description: The Cathepsin B Inhibitor Screening Assay Kit is designed to measure the protease activity of Cathepsin B for screening and profiling applications. The Cathepsin B assay kit comes in a convenient 96-well format, with purified Cathepsin B, its fluorogenic substrate, and Cathepsin buffer for 100 enzyme reactions. In addition, the kit includes the cathepsin inhibitor E64 for use as a control inhibitor.
Materials Required But Not Provided:
Synonym(s): Cathepsin B, CTSV, Amyloid Precursor Protein Secretase, CTSB, APP Secretase, activity assay kit
Supplied As: The Cathepsin B assay kit comes in a convenient 96-well format, with purified Cathepsin B, its fluorogenic substrate, and Cathepsin buffer for 100 enzyme reactions.
Format: COMPONENT:
Instructions for use: See assay kit data sheet for detailed protocol.
Storage / Stability: Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival.
Application(s): Great for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Reference(s): 1. Aggarwal, N., & Sloane, B. F. (2014). Cathepsin B: multiple roles in cancer. PROTEOMICS– Clinical Applications 8(5-6), 427-437 2. Siklos, M., BenAissa, M., & Thatcher, G. R. (2015). Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors. Acta Pharmaceutica Sinica B, 5(6), 506-519 Warning(s): Avoid freeze/thaw cycles.
Scientific Category: Protease
Product Type: Assay Kit
Data shown is lot-specific. Contact us for specific information on other lots.
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