Human UTX, also known as KDM6A (GenBank Accession No. NM_021140) (a.a. 1-1401) with C-terminal FLAG-tag, MW = 155 kDa, expressed in Sf9 cells via a baculovirus expression system.

O15550

KDM6A

40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 20% glycerol, and 80 µg/ml FLAG peptide

Aqueous buffer solution

>6 months at –80°C.

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

1. Greenfield, A., et al., (1998). Hum. Mol. Genet. 7(4):737–42.
2. Agger, K., et al., (2007). Nature. 449(7163):731–4.1. Suzuki, T., et al., (2013). J Med Chem. 56(18):7222-31. 

Application Reference(s):
1. Inhibition of KDM4A activity as a strategy to suppress interleukin-6 production and attenuate colitis induction (2017)
2. Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity (2013)

Avoid freeze/thaw cycles.

Demethylase

Recombinant Protein