Tubastatin A is a potent HDAC6 inhibitor. It demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50 >16 µM), excluding HDAC8 (IC50 = 0.9 µM). Tubastatin A induces a-tubulin hyperacetylation at 2.5 µM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, it displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 µM.
| 产品名称 | Tubastatin A hydrochloride - Inhibitors / Activators - Deacetylase(s) |
| 产品货号 | 27108 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 371.9 Da
CAS Registry #: 1310693-92-5
Formula: C20H21N3O2•HCl
Description: Purity: ≥98% by HPLC. Biological Activity: Inhibits HDAC6 with IC50 = 15 nM and HDAC1 with IC50 = 16.4 µM.
Solubility: Solubility in DMSO is 8 mg/ml, and in water and ethanol is < 1 mg/ml.
Format: White to off-white crystalline solid; granular or powder.
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s): 1. Butler, K.V., et al. J Am Chem Soc. 2010; 132(31): 10842-6. Application References: Scientific Category: HDAC
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
|
| 产品资料 |
