Human E1A binding protein p300, also known as EP300, KAT3B, or RSTS2, GenBank Accession No. NM_001429, a.a. 965-1810, with N-terminal His-GST-tag, MW=125 kDa, expressed in Sf9 cells via a baculovirus expression system.

Q09472

EP300, KAT3B, RSTS2, E1A binding protein, cbp

≥357 pmole/min/µg

40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, and 20% glycerol.

Aqueous buffer solution

>6 months at –80°C

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

1. Gui, Y., et al., Nat. Genet. 2011 Aug 7; 43(9) : 875 – 878.
2. Morin, R.D., et al., Nature. 2011 Jul 27; 476(7360) : 298 – 303.
3. Zhao, Z., et al., Brain Res. Bull. 2011 Oct 10; 86(3-4) : 189 – 194.

Product Specific Reference(s): 
1. Furdas, S.D. et al., Med. Chem. Commun. 2014; 5: 1856-1862.
2. Liao, D., et al., Cancer. Epigenetics. 2005; 1238: 539-548. 

Avoid freeze/thaw cycles.

Acetyltransferase

Recombinant Protein