| 产品名称 | PD-L1 (CD274), Fc fusion (Human) HiP™ - HiP™ Proteins |
| 产品货号 | 71104-3 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 1 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: HEK293
MW: 52 kDa
Genbank #: NM_014143
Tag(s): C-terminal Fc fusion (Human IgG1)
a.a: 19–239
Background: PD-L1 is involved in the costimulatory signal essential for T-cell proliferation and production of IL-10 and IFNgamma. Interaction with PD-1 inhibits T-cell proliferation and cytokine
production, and down-regulates the immune response. PD
Description: Human secreted Programmed Cell Death 1 Ligand 1 (PD-L1)-Fc fusion protein, also known as CD274 and B7 homolog 1 (B7- H1), GenBank Accession No. NM_014143, amino acids 19-239, fused at the C-terminus to the Fc portion of human IgG1, expressed in a HEK293 cell expression system. MW = 52 kDa. UniProt Q9NZQ7
Synonym(s): Programmed Cell Death 1 Ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, CD274, PDCD1L1
Assay Conditions: PD-L1 binding to PD-1
was tested following protocol for BPS Cat.
#72005. Briefly, wells were coated with 10
ng of PD-L1 in PD-1 assay buffer. Varying
concentrations of biotinylated PD-1 was
added and wells were incubated at room
temp. for 2 hours before adding strep-HRP,
followed by chemiluminescent substrate.
Luminescence was read on a
chemiluminescent plate reader.
Formulation: 8 mM phosphate, pH 7.4,
110 mM NaCl, 2.2 mM KCl, and 20%
glycerol
Format: Aqueous buffer solution
Storage / Stability: At least 6 months at –80°C.
Application(s): Useful for the study of protein-protein interaction and in vitro and in vivo protein function.
Reference(s): 1. Freeman, G.J., et al., J Exp Med. 2000 Oct 2;192(7):1027-34. Application Reference(s):
Notes: HiP™ indicates a high purity protein with ≥90% purity as measured by gel filtration. This protein runs at a higher M.W. by SDS-PAGE due to glycosylation.Warning(s): Avoid freeze/thaw cycles. Protein may be diluted to ≥ 100 μg/ml in PBS + glycerol and stored at -80°C.
Scientific Category: Immunotherapy
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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