Human secreted Programmed Cell Death 1 (PD-1)-Fc fusion protein, also known as CD279, PDCD1, and SLEB2, GenBank Accession No. NM_014143, amino acids 25-167 with an I126A mutation, fused at the C-terminus with the Fc portion of human IgG1, and C-terminal AviTag™, expressed in a HEK293 cell expression system and enzymatically biotin-labeled using AviTag™ technology. MW = 44.5 kDa. This protein runs at a higher MW by SDS-PAGE due to glycosylation.

Q15116

Programmed cell death 1, PDCD1, PD-1, PD1, SLEB2, CD279, HPD-L

8 mM Phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol

Aqueous buffer solution

At least 6 months at -80°C.

Useful for the study of protein-protein interaction and in vitro and in vivo protein function.

1. Freeman, G.J., et al., J. Exp. Med. 2000 Oct 2;192(7):1027-34.
2. Dong, H., et al., Nat Med. 1999 Dec;5(12):1365-9.

HiP™ indicates a high purity protein with ≥90% purity as measured by gel filtration.

Avoid freeze/thaw cycles. Protein may be diluted to 100 μg/ml in PBS + glycerol and stored at -80°C.

Immunotherapy

Fc Fusion Protein